Scientists have discovered evolutionary changes that can explain why some human immune cells are less effective in combating solid tissue tumors than other primates.
This was reported by Eurekalert with reference to the results of a study by scientists from the Combined Cancer Center of the University of California in Davis (USA).
It is noted that scientists have discovered a tiny genetic difference in one amino acid between people and inhuman primates in an immune protein called FAS (FASL) ligand:
- This genetic mutation makes FASL protein vulnerable to disconnecting plasmine – an enzyme that often increases in aggressive tumors.
- This vulnerability is unique to people and is not found in other primates, such as chimpanzees.
Scientists say that the evolutionary mutation in FASL may have contributed to an increase in the size of the brain in people. – But in the context of cancer, this was an unfavorable compromise, since the mutation gives a certain tumor the ability to disable part of our immune system.
FASL is the protein of the immune cell membrane, which triggers the programmed death of cells called apoptosis. Immune cells use apoptosis to destroy cancer cells.
According to scientists, this discovery, in particular, can explain why some types of immunotherapy can be effective in blood cancer, but not in the fight against solid tissue tumors.
Source: Eurekalert
The brain of people was compressed, a scientist was created
Honorary people have such an acceleration brain, creating a scientist
Source: Racurs
I am David Wyatt, a professional writer and journalist for Buna Times. I specialize in the world section of news coverage, where I bring to light stories and issues that affect us globally. As a graduate of Journalism, I have always had the passion to spread knowledge through writing.