Take the napkin, “freeze”, then cut it into very thin strips that can be observed under a microscope; histology has become important for both research and diagnosis to better observe cells, characterize pathology, or select a treatment modality. But it has a big drawback. the studied sample, with a maximum thickness of several micrometers, is far from faithfully reflecting the processes taking place in the entire organ. “ We are organized three-dimensionally, not in segments ! »says Alain Chedotal, who specializes in the development of neural circuits at the Vision Institute in Paris. “ Cutting causes deformations, so we lose information about the location of different cells »adds Perrine Paul-Gilloteaux, CNRS research engineer in image processing and scientific director of the MicroPICell cellular imaging platform (UAR Biocore, Inserm, CNRS, University and University Hospital of Nantes).
But without these reductions it is impossible to consider…
Source: Le Figaro
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