A new study opens the potential of slowing down or even partial restoration of the functioning of the providing Alzheimer’s patient patients.
Scientists from the University of California in San Francisco and the Gladstone Institute have found that some cancer drugs may reverse that changes in the brain caused by Alzheimer’s disease, Medicalxpress reports.
Researchers have compared changes in expressing genes in the brain of patients with Alzheimer’s exposure to more than 1300 approved drugs. They have announced a combination of two drugs capable of leveling negative changes in neurons and glial cells – the same main type of cells that undergo damage to this form of dementia.
The team also reviewed millions of electronic medical records and noticed that patients who took some of these drugs for other reasons were more likely to hurt Alzheimer’s. Further testing of mice with an aggressive form of the disease has shown that the integration of two cancer, tiesol (treatment of breast cancer) and irinothens (against colon and lung cancer), reduced brain decay, decreased formation of toxic protein deposits and even restored memory.
Professor Marina Sirota, one of the research managers, noted that the Alzheimer’s disease was extremely complicated for studying because of the depth and many changes he caused in the brain, but modern computing tools were possible to approach the problem comprehensive.
Based on the expression database of genes in human cells, the team narrows the list of drugs from 1300 to 86, then up to 10, of which only five have approved the FDA. Of these, two most promising compounds have fallen into further laboratory testing.
“If the independent sources of data – genetic expressions and medical records – led us to both drugs, then they showed effectiveness in the disease model, maybe we were really on the right track,” the orphan added.
Researchers hope that results can be quickly adapted to clinical conditions.
We remind you, earlier it was reported that in the United States approved a blood test for Alzheimer’s disease.
In the UK, they successfully experienced new leukemia therapy without chemotherapy
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Source: korrespondent
I am Ben Stock, a passionate and experienced digital journalist working in the news industry. At the Buna Times, I write articles covering technology developments and related topics. I strive to provide reliable information that my readers can trust. My research skills are top-notch, as well as my ability to craft engaging stories on timely topics with clarity and accuracy.