This is a step towards finding new ways to treat neuropsychiatric disorders in humans.
Scientists transplanted into the nervous system of newborn mice that repair pieces of human brain tissue grown in the laboratory, writes Science Alert.
“Three-dimensional stem cell-derived organelles resembling a simplified model of the human cerebral cortex were connected and integrated with the surrounding tissue in the cortex of each mouse, forming a functional part of the rodent’s own brain. which reflects sensory-related activity,” the researchers note.
This experiment gives scientists a new platform to model human brain development and disease in a living system.
“Much of the work my lab does is motivated by this mission to try to understand mental disorders on a biological level so that we can actually find effective therapeutics. .” , or at least they are related to the unique characteristics of the human brain, have contributed to the understanding of the biology of these conditions,” the scientists said.
Human cortical organelles were cultured in a dish and then transplanted directly into the somatosensory cortex (a region of the brain responsible for receiving and processing sensory information) in rat pups just a few days old. These mice were allowed to grow into adults for an additional 140 days (mice become fully sexually mature between 6 and 12 weeks).
The scientists then studied the mice. They genetically engineered the organelles to respond to simulated blue light by firing neurons when blue light shone on them. Stimulation of human neurons was produced when rats were trained to lick their noses to obtain water. Later, when the organelles were illuminated with blue light, the mice automatically licked their lips, showing a response not seen in the control groups.
This indicates that the organoid not only functions as part of the rat’s brain, but can also direct reward-seeking behavior.
Brain cells cultured from three patients with a genetic disorder called Timothy’s syndrome were also used for some organoids. It affects the heart, fingers, and nervous system and often results in early death.
Remember that early Korean scientists created a holographic microscope that allowed you to see through the skull and visualize the brain.
Scientists explain the decline in the modern human brain
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Source: korrespondent
