The data obtained help to create ideas about the necessary mechanisms for slower aging.
Researchers at Boston University School of Medicine and Tufts Medical Center studied the immune cell types of centenarians over 100 years old. Certain mechanisms of work were found in them. This is stated in the journal EBioMedicine.
It has been mentioned that one of the causes of aging is the deterioration of the immune system. But in centenarians, these processes happen more slowly, because their immune system is more resilient.
“The study involved the sequencing of single-celled peripheral blood mononuclear cells (PBMCs), immune monocyte cells that circulate in the blood. The results of the analysis were combined with two publicly available single-cell RNA sequencing ( scRNA-seq) datasets to study compositional and transcriptional changes in the human immune system throughout life and in extreme old age. We then used state-of-the-art computational methods,” the report said.
Thus, it became known that centenarians have a unique composition of cells that generate a strong immune response.
“These protective factors allow their immune system to adapt after exposure to infections and then recover quickly. Naturally, with age, this ability gradually decreases, but more slowly than carriers of conventional types of immune cells. The findings of the work are also consistent with previous discoveries,” the scientists summarized.
Recall that early scientists from the Buck Institute and Stanford University developed a system that, based on the analysis of certain proteins in the blood, allows you to determine a person’s biological age, predict the risk of development of cardiovascular diseases and estimate life expectancy.
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Source: korrespondent
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