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coronavirus SARS-CoV-2 According to Spanish scientists involved in the investigation, which began at the beginning of the pandemic in March 2020, it turned out that the virus responsible for COVID-19 can cause rapid aging in people.
Scientists have confirmed the involvement of cellular aging in the consequences COVID-19 and the relationship between coronavirus mortality and morbidity and the inflammatory response and tissue degradation associated with cell aging in the body.
This was confirmed by a team of researchers led by the Center for Molecular Biology Severo Ochoa (Supreme Council for Scientific Research and the Autonomous University of Madrid), who published their results in a journal. aging cell.
Aging is a condition in which aged cells lose their ability to divide and contribute to the functioning of the body, but do not disappear, but accumulate over the years in almost all organs, where they secrete inflammatory molecules and enzymes that destroy tissues. .
The CSIC reported that the published work highlights the importance of considering the impact of the pro-inflammatory environment created by these cells on the effects caused by COVID-19.
When did the global pandemic start due to corona virus The Carlos III Institute of Health awarded a grant to 16 researchers from eight institutions to study the relationship between symptoms caused by the virus and senescent cells, also known as “zombie cells” because of their behaviour.
“The most interesting thing is that these cells are metabolically overactive, which makes them harmful to the body, creating a chronic pro-inflammatory scenario in the tissues where they accumulate. The idea was to see if the virus, when it infects, amplifies the negative effects of aging cells,” explained Cayetano von Kobbe, a researcher at the Center for Molecular Biology who led the project.
Follow-up studies performed on mice that were humanized and therefore susceptible to SARS-CoV-2 infection showed the role of senescent cells in creating an inflammatory environment that contributes to the development of symptoms due to infection. COVID-19.
Researchers have confirmed the importance of cell aging in mortality and morbidity caused by SARS-CoV-2, which can be extrapolated to data obtained during the coronavirus pandemic. COVID-19.
Cell aging
In the biosafety lab at the Severo Ochoa Center for Molecular Biology, researchers observed the ability of the virus to “age us rapidly.”
Tissue aging is directly related to persistent COVID (also called post-COVID syndrome), and although it does not have an immediate effect on adults, it does show a large role in SARS-CoV-2 morbidity and mortality seen in the elderly, detailed in the CSIC.
Von Kobbe wondered what would happen when infected people lived to old age with older than normal tissues, and stressed the importance of studying the pathologies associated with infection now. persistent COVID. (EFE)
Source: RPP
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