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New universal cancer vaccine showed effectiveness in mice

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Despite the possible risks associated with disruption of the operation of the immune system, researchers believe that this direction has great potential.

Scientists have taken an important step in creating a universal cancer vaccine, which can fight a wide variety of tumors, Sciencealert reports. Studying team from the University of Florida has shown that the new approach can activate the immune system to attack it even with tumors that usually remain lost to various factors.

The drug is created based on the MRNA, which produces signal proteins that wake up to the immune system and make the tumor cells more vulnerable. It is important that these proteins are not specific for a specific type of cancer, but act as a “signal of anxiety” for the body, which attracts even immune cells that usually do not respond to oncology.

“We have found that using a vaccine, which stimulates a strong immune response without reference to a certain type of cancer, can cause a very strong antitumor response,” explained neurologist Dwayne Mitchell. According to him, it opens up to create a “universal” vaccine, which can be applied to a wide range of patients.

Another major element of therapy is the inhibitors of immunity control points – anti -cancer drugs that relieve restrictions from immune response. In integration with the vaccine, they gave the most pronounced effects: in mice there is a strong antitumor reaction even against neoplasms that are considered resistant to treatment. In some cases, the tumors are completely lost.

Specialists emphasize that any immunity intervention is risks of side effects, but the first results seem to be encouraging. The team is already working on new drug formulas and preparing for clinical trials in public that will help evaluate the effectiveness and safety of the approach. Scientists also want to check if the vaccine can not only treat the vaccine, but also prevent cancer.

We note, earlier it was reported that air pollution was associated with mutations that cause lung cancer.

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Source: korrespondent

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