This study opens a new class of nucleic acid drug candidates with a mechanism unmatched in the scientific world today.
Scientists have developed artificial DNA sequences that can effectively attack cancer cells. Medicines based on nucleic acids – NA in DNA and RNA are increasingly emerging as a new treatment for various diseases, according to New Atlas.
The development belongs to researchers from the University of Tokyo. It is noted that drugs based on nucleic acids are difficult to distinguish between healthy cells from cancer cells, so dangerous immune reactions can occur. To do this, researchers have developed artificial DNA molecules that only affect cancer cells.
The shape of the molecules resembles hairpins. Therefore, they have been called “oncolytic hairpins” – oHP.
“We synthesized these molecules chemically with DNA pairs specifically designed to interact with an mRNA sequence (miR-21) that is overexpressed in certain types of cancer cells When miR-21 encounters oncolytic hairpins, they join them and then hang, thus forming a longer strand of DNA, which sends a signal of their presence to the immune system, which attacks and destroys in cancer cells,” the scientists said.
They tested this method in laboratory cultures of human cervical and breast cancer cells, as well as melanoma cells in live mice. Oncolytic hairpins have been proven effective in all cases, not only in killing cancer cells, but also in preventing the growth of cancerous tissue.
It will be remembered that earlier at the Medical University of South Carolina an effective natural cure for cervical cancer was found.
In the United States invented a drug for the treatment of cancer with 100% effectiveness
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Source: korrespondent
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