It began as an epidemiological interest. In the 1920s in Sweden, Dr. Carl Naslund was surprised that children vaccinated with the newly introduced BCG died two to three times less often than others. His version. Bacille Calmette-Guerin, the tuberculosis vaccine developed at the Lilly Pasteur Institute and first tested in 1921, would have a “non-specific effect”. In other words, side effects, but desirable ones that will protect against pathogens other than the one initially targeted. Since then, observations have accumulated, especially in Africa. BCG (and other live virus vaccines, such as oral polio vaccine or measles vaccine) can prevent up to 30% of infections in infants. , especially respiratory.
Studies have shown that this protection “associated with epigenetic changes (changes…
Source: Le Figaro