After the pouring of the stem cell, ten of the twelve participants in the study completely abandon the insulin.
Revolutionary stem therapy has provided encouraging results in the treatment of severe type 1 diabetes, Sciencealert reports. Of the 12 participants in the clinical study who received an infusion of stem cells, ten stopped taking insulin after 12 months.
The new therapy was developed by the biotechnological company vertex pharmaceutical (Boston, USA). Its essence is to replace the lost insulin production by infusion of pancreatic islands of islets created from human stem cells. This method is called zimislecel.
Prior to infusion, all patients underwent an immunosuppressive therapy needed to reduce the risk of cell decline. As a result, the introduced cells began to produce insulin in safe doses, automatically responding to glucose in the blood.
“These results have shown that Zimislecel cells work and are capable of self -regulation,” the study under the leadership of the surgeon Ryhman from the University of Toronto.
Side effects (largely reducing immune defense and impaired renal function) are associated with immunosuppression, and not the therapy itself. Unfortunately, two participants died – one from infection after surgery, the other from complications that were not related to treatment.
Despite this, not a single serious complication directly related to the introduction of cells has been recorded, so clinical study has been passed in the third stage.
The success of therapy can be a point of treating a disease, which until recently is considered unable to.
The results have been published in the New England Journal of Medicine.
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Source: korrespondent
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